Two NFC West rivals get together to close out Week 10 of the NFL season, as the Los Angeles Rams hit the road to face the San Francisco 49ers and we speculate with our Monday Night Football picks.
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The big news this week is the Rams’ signing of WR Odell Beckham Jr., which actually came on the same day that fellow WR Robert Woods tore his ACL in practice. Woods will now miss the rest of the season, making the Beckham signing that much more important.
This article will identify the top three NFL picks from tonight’s Rams at 49ers game. So, let’s dive right in and see what they are.
Rams at 49ers – Monday Night Football Picks
49ers, +3.5 – buy to +4.5, -130 (Caesars)
The 49ers are 4-0 against the Rams, with two of those last three wins coming by a field goal. This is an interesting scenario because it has a lot to do with the head coaching on both teams.
49ers head coach Kyle Shanahan has been especially crafty in the matchup against Sean McVay of the Rams, both of which are incredibly bright young coaches. However, with this element and the 49ers getting more than a field goal here at home in Santa Clara, I will be taking them with the points in their own building.
Over 50 Points, -110 (DraftKings)
There is a decent amount of sharp money heading towards o49 in this 49ers-Rams matchup. Part of the reason will certainly include Rams QB Matt Stafford, who will be playing his first game in this rivalry.
In addition, the 49ers are healthier than they’ve ever been this season. San Francisco is coming off a brutal loss at home last week to Arizona, so I believe this will make them very inspired for this contest.
Plus, at 3-5, the 49ers don’t have many lifelines left, so the desperation of this offense should come to fruition tonight.
Brandon Aiyuk – Over 45.5 Receiving Yards, -115 (PointsBet)
With 49ers WR Deebo Samuel likely to draw shadow coverage from Rams CB Jalen Ramsey, this should open the door for Aiyuk to have a big game tonight.
After a rough start to the season, Aiyuk has grabbed 10 of his 15 targets for 134 yards and a touchdown. In fact, that is more catches and yards than what he had in the previous five games combined; it was also one fewer target than he saw in the first five games.
